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Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's active metabolites. The outcome of CYP3A4 inducers on cariprazine publicity hasn't been evaluated and the net effect is unclear.pentobarbital will lower the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monito